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Chaudhary, Jaideep

One or more keywords matched the following properties of Chaudhary, Jaideep

Property	Value
overview	Our research focus is to understand molecular basis of prostate cancer development and progression. We currently have two projects in this area. The first project is focused on understanding the role of Inhibitor of differentiation 4 (Id4) in prostate development, castration resistant prostate cancer and chemo-sensitivity around the p53/ PTEN pathway. The second, project addresses how inflammation and infection causes prostate cancer. The observation that body’s failure to effectively fight inflammation or infection causes cancer is the basis of this project. Our group is looking at molecular signatures in genes (SNP and expression) that cause inflammation that we hope will indicate if a person has increased susceptibility to prostate cancer. Our overall hypothesis is that body’s inflammatory response, under the genetic control and influenced by race, environment and dietary habits is a major determinant of prostate cancer.

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overview

Our research focus is to understand molecular basis of prostate cancer development and progression. We currently have two projects in this area. The first project is focused on understanding the role of Inhibitor of differentiation 4 (Id4) in prostate development, castration resistant prostate cancer and chemo-sensitivity around the p53/ PTEN pathway. The second, project addresses how inflammation and infection causes prostate cancer. The observation that body’s failure to effectively fight inflammation or infection causes cancer is the basis of this project. Our group is looking at molecular signatures in genes (SNP and expression) that cause inflammation that we hope will indicate if a person has increased susceptibility to prostate cancer. Our overall hypothesis is that body’s inflammatory response, under the genetic control and influenced by race, environment and dietary habits is a major determinant of prostate cancer.

One or more keywords matched the following items that are connected to Chaudhary, Jaideep

Item Type	Name
Grant	Inhibitor of Differentiation Gene Expression and Function in Prostate Cells
Academic Article	Inhibitor of differentiation 4 (Id4) is a potential tumor suppressor in prostate cancer.
Academic Article	2'-5' oligoadenylate synthetase 1 polymorphism is associated with prostate cancer.
Academic Article	The myxovirus resistance A (MxA) gene -88G>T single nucleotide polymorphism is associated with prostate cancer.
Academic Article	Id4 deficiency attenuates prostate development and promotes PIN-like lesions by regulating androgen receptor activity and expression of NKX3.1 and PTEN.
Academic Article	Increased expression of bHLH transcription factor E2A (TCF3) in prostate cancer promotes proliferation and confers resistance to doxorubicin induced apoptosis.
Academic Article	Inhibitor of differentiation 1 (Id1) and Id3 proteins play different roles in TGF? effects on cell proliferation and migration in prostate cancer cells.
Academic Article	Epigenetic inactivation of inhibitor of differentiation 4 (Id4) correlates with prostate cancer.
Academic Article	Id1 and Id3 expression is associated with increasing grade of prostate cancer: Id3 preferentially regulates CDKN1B.
Academic Article	EZH2 dependent H3K27me3 is involved in epigenetic silencing of ID4 in prostate cancer.
Academic Article	Interferon inducible antiviral MxA is inversely associated with prostate cancer and regulates cell cycle, invasion and Docetaxel induced apoptosis.
Academic Article	Inhibitor of differentiation 4 (ID4) acts as an inhibitor of ID-1, -2 and -3 and promotes basic helix loop helix (bHLH) E47 DNA binding and transcriptional activity.
Academic Article	Id4 promotes senescence and sensitivity to doxorubicin-induced apoptosis in DU145 prostate cancer cells.
Academic Article	Id4 dependent acetylation restores mutant-p53 transcriptional activity.
Academic Article	-174G/C polymorphism in the interleukin-6 promoter is differently associated with prostate cancer incidence depending on race.
Academic Article	Inhibitor of differentiation 4 (ID4) inactivation promotes de novo steroidogenesis and castration-resistant prostate cancer.
Academic Article	Prostate cancer epigenome.
Academic Article	ID4 promotes AR expression and blocks tumorigenicity of PC3 prostate cancer cells.
Academic Article	Intra-tumoral delivery of functional ID4 protein via PCL/maltodextrin nano-particle inhibits prostate cancer growth.
Academic Article	Basic helix loop helix (bHLH) transcription factor 3 (TCF3, E2A) is regulated by androgens in prostate cancer cells.
Academic Article	ID4 regulates transcriptional activity of wild type and mutant p53 via K373 acetylation.
Academic Article	Inactivation of ID4 promotes a CRPC phenotype with constitutive AR activation through FKBP52.
Academic Article	Non-redundant inhibitor of differentiation (Id) gene expression and function in human prostate epithelial cells.
Academic Article	The impact of genomic alterations on the transcriptome: a prostate cancer cell line case study.
Academic Article	ID1-, ID2-, and ID3-regulated gene expression in E2A positive or negative prostate cancer cells.
Academic Article	Calcitonin promotes in vivo metastasis of prostate cancer cells by altering cell signaling, adhesion, and inflammatory pathways.
Academic Article	Differential effects of cholesterol and phytosterols on cell proliferation, apoptosis and expression of a prostate specific gene in prostate cancer cell lines.
Concept	Prostatic Neoplasms

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Prostatic Neoplasms